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Monthly Archives: April 2013

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Fool’s gold, lost treasures, and the randomized clinical trial

Fool’s gold, lost treasures, and the randomized clinical trial

April 16, 2013Written by David J Stewart, Razelle Kurzrockin Articles

Abstract Background: Randomized controlled trials with a survival endpoint are the gold standard for clinical research, but have failed to achieve cures for most advanced malignancies. The high costs of randomized clinical trials slow progress (thereby causing avoidable loss of life) and increase health care costs. Discussion: A malignancy may be caused by several different mutations. Therapies effective vs one mutation may be discarded due to lack of statistical significance across the entire population. Conversely, expensive large randomized trials may have sufficient statistical power to demonstrate benefit despite the therapy only working in subgroups. Non-cost-effective…

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